Scientists report today on the ability to create sperm from bone marrow cells. Initially performed in men, the technique could potentially be performed in women and lead to a sperm cell made from a woman’s body. You got it right- that cell could then fertilize an egg leading to the first female-female conception in human history.
As a fertility specialist I couldn’t resist this story and wanted to share the reality and the hype. Prof. Karim Nayernia, Professor of Stem Cell Biology at the Instatute of Human Genetics at the Univeristy of Mewcastle on Tyne led the project reported in Biology of Reproduction. A summary of the study was released in the Independent today.
The researchers said they had already produced early sperm cells from bone-marrow tissue taken from men. They believe the findings show that it may be possible to restore fertility to men who cannot naturally produce their own sperm.
But the results also raise the prospect of being able to take bone-marrow tissue from women and coaxing the stem cells within the female tissue to develop into sperm cells, said Professor Karim Nayernia of the University of Newcastle upon Tyne.
The report suggests that “Scientists are seeking ethical permission to produce synthetic sperm cells from a woman’s bone marrow tissue after showing that it possible to produce rudimentary sperm cells from male bone-marrow tissue.”
The Two Mommy- No Daddy Baby Making Research Plan:
“Theoretically is it possible,” Professor Nayernia said. “The problem is whether the sperm cells are functional or not. I don’t think there is an ethical barrier, so long as it’s safe. We are in the process of applying for ethical approval. We are preparing now to apply to use the existing bone marrow stem cell bank here in Newcastle. We need permission from the patient who supplied the bone marrow, the ethics committee and the hospital itself.”
If sperm cells can be developed from female bone-marrow tissue they will be matured in the laboratory and tested for their ability to penetrate the outer “shell” of a hamster’s egg - a standard fertility test for sperm.
“We want to test the functionality of any male and female sperm that is made by this way,” Professor Nayernia said. But he said there was no intention at this stage to produce female sperm that would be used to fertilise a human egg, a move that would require the approval of the Human Fertilisation and Embryology Authority.
This same group reported last year that they created artifical sperm from embryonic sperm cells in mice.
(They) isolated stem cells from blastocysts, which are early-stage embryos only a few days old. From these cells were extracted those that would go on to form sperm, known as spermatogonial stem cells (SSCs). The SSCs were then cultured in the laboratory, and when some developed into sperm, they were injected into female mouse eggs and grown into early-stage embryos. The embryos were transplanted into the wombs of surrogate mothers.
The Genetic Disaster That Could Result: Faulty Imprinting. There is a huge genetic time-bomb here. The genetic phenomenon called imprinting. This describes the situation where a particular gene is marked or imprinted with a tag that says if it came from the mother or father- and more importantly only one of the other is active. For example for a particular gene it’s possible that only the maternal copy gene could be active and the copy that comes from the mother could be switched off. If this process goes wrong (mom and dad copy mistakes) then severe genetic diseases can result.
A description of imprinting follows and a detailed description is here and here
However, it is now known that the expression of a small number of the 30,000 or so genes in the cells depends on whether the gene copy was passed down from the father or the mother. This process, whereby the expression of a gene copy is altered depending upon whether it was passed to the baby through the egg or the sperm, is called imprinting. The term “imprinting” refers to the fact that some chromosomes, segments of chromosomes, or some genes, are stamped with a “memory” of the parent from whom it came: in the cells of a child it is possible to tell which chromosome copy came from the mother (maternal chromosome) and which copy was inherited from the father (paternal chromosome). This expression of the gene is called a “parent of origin effect” .
UPDATE:Â this same group of scientists havbe repeated and extended this research moving closer to a human all female baby- read about their follow-up project here
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56 users responded in this post
I knew it! I knew the day would come when men would becom obselete!! HAHAHAHAHAHA
I knew it! I knew the day would come when women would becom obselete!! HAHAHAHAHAHA
wow i love this article. can’t wait to use it on myself…
wow.. good thing i was born late, at least i can try this out. cool
wow it would be great if they had this figured out in time for me and my girlfriend to have a baby this way.
I personally think that this is insane. There is a reason men and woman were created to engineer their own certain aspects so that when they are put together, they create human life. I do however agree with the use of invitrofertilisation to help infertile couples to concieve a child.
I love women, holding her, her emotions, her opinions, her direction, cold nights with her, telepathy with her, and she is an integral part of my life. I hope this never catches on- that we become obsolete!
lol..perfect…no more ugly babies!..lmao
notradomus said men would go into 3 groups one being slaves to woman.house servants.then breeders.satan is big brother,using scientist and governments and hollywood.we are in alote of trouble.
this should not be allowed.bah bah.off to the chopping block.woman please dont let all this go to your head and lets have the LOVE, not to be confused with sex.yes alote of men who are power freaks controlling but also so are some woman.this is what they want for man and woman not love one another.down with rothchilds,zion and big brother(SATAN)LETS PRAY TO JESUS he is going to help the good
I would love to be used as only a breeder.
Does this mean that women can go F___ themselves? I’ve been thinking that for years. Behold, it’s now a near reality.
I am not too sure I agree with this.
Maybe if it is used ONLY for males who cannot produce it themselves. Other then that I think it is a horrible idea. Where is the love?
A child with female-female parents is going to have some psychological problems. In order for children to develop properly mentally they need a Male and a Female parent. (As seen through kids who only have one parent)
I think people who find children with only one parent underdeveloped mentally are ignorant. There are plenty of situations where children flourish when an abusive parent is removed, when someone dies in war and leaves their family, when someone dies from illness or is lost by some disaster. In order for children to develop properly, they need to have the proper mental capacity to do so, nothing more.
Anonymous: Do some reasearch. Psychologists frequently do studies about what parenting conditions lead to the most “successful” (stable) children and they frequently find that to two mommies are best.
sweet. you go science!
by the way; typical men to say that this would be WRONG just because they are so afraid to be useless. blah blah.
some say this is not a good thing.people always fear what they dont understand.(Anonymous)you cant say its ok for some people to use and not others.Thats why their is free will,not for you to judge.You need to do some research,because i have never seen a study proving that a gay couples child was more messed up than a straight couples child. all should know that a baby between two people weather its male & female, male & male, female & female, that it is being made from love by two people that are very much in love.a baby should not be created for anything less.Weather or not a sperm cell from a man or woman is used, it is still only going to be for the people who want it.doesnt make men abselete,i love all the men in my life(family,freinds) i still love them.This wouldnt make me love them any less.If all goese well with this gay’s and couples who are not fertal can still share one of lifes most precious gift.and know they come from 2 people who love him or her,& not have to worry about what kind of person it came from,i dont know about you but i would be scared to death to use just some random sperm donors sperm that i knew nothing about.at least this way i would know its from someone who i love and care deeply about, my soulmate.Less hate more love.if this would cuase any harm to the developement of making a baby i wouldnt do it,but if the baby forms perfectly fine then it has my support and blessings.
I beleive this is old news and children have already been born in this way. Remember people (with money) have assess and science try these things long before it is release to the public.
All hell.. I’m all for it… Science rules!.. it’s about damn time something like this came into action. sOME WOMEN WILL Prefer the old way (more power to them)..while the rest of us won’t have to bother dealing with men….(THANK GOD). And as far as where’s the love between men and women…HA! there was never any love…Women have always been just a way for men to get their rocks off…but oh well maybe this will change that…(Hopefully anyways).
none of these “techniques” will ever be available in USA, the tightest restrictions will ensure that choices for people wishing families are LIMITED.
of course, that same controlling group refusing the public the right to chose “reproductive possibilities”
have NO ethical qualms when it comes to producing and disecting embryos for someone else’s health needs rather than permitting
the embryo implantation so IT may develop into all the potential of a child and loved by a family.
ethicists are a nasty bunch, really, they seek to tell the old and sick and helpless that it is their DUTY to die so that funds and care may be given to others deemed worthy to survive.
be glad however for ASIA, folks wishing choices might well consider heading overthere for what will be unavailable (to the public) here. for sure ASIA will make developments as these AVAILABLE.
i believe that this technique will be released to the public VERY soon. its amazing that children can be born not matter if its through a straight couple or gay couple. having a child is going to be the best, i KNOW this will work!
i do have a belief that this has already happened but people are debating whether for it to be released to the public. i read that someone read something about both female AND male children were born without a male. i also read that it IS possible but to the really wealthy persons.
anyways, GO SCIENCE GO!
You people are retarted! just because you women think that “OH MEN! I HATE THEM BECAUSE THEY F’ED ME OVER” tough! you shouldnt go gay just because the world is cruel! “OH WOMEN UNDERSTAND ME BETTER, THAT IS WHY WE SLEEP TOGETHER” HAHA thats stupid!!!! I feel bad for you but just because u dont have the luck with men and picking out the good ones doesnt mean you can say yes to this abomination! YEA YOU HAVE FREE WILL AND SHIT BUT SO DID YOUR MOM AND YOUR DAD! To bad they said OK to have you! i dont even think it is ok for this to happen for men that cant have kids with thier own wifes. there is a reason behind it all. look at all the kids for adoption. go adopt!~
what is your problem there ‘.,.’ not alot of people HATE men they just dont like them SEXUALLY, some girls just like girls alright? there’s people like transgenders and stuff too. what if YOU couldnt share something with your partner IF you have one?! but whatever its your opinion, i’m over it, YOU get over it. and its not our problem that some people cant take care of their kids so their up for adoption, HOW ABOUT if you cant take care of your kid YOU DONT HAVE IT, so i respect adoption and stuff but wholey calm down. like i said before SOME GIRLS ARENT ATTRACTED TO MEN SEXUALLY! thats why there is lesbians and the ones who love eachother that want kids together. NO MATTER WHO ANYONE IS WITH they SHOULD be able to have kids together so i think this is an amazing thing to happen.
I believe this is an amazing ‘breakthrough’ for two women to be able to conceive their own child.
It honestly makes me sick to my stomach reading articles where one male is making sperm donations all over the world - fathering thousands of children and taking no responsibility for them. The men who leave negative replies on this website are truely THREATENED by science and obviously have their own ‘hangups’with lesbians.
I laugh thinking about the lonely men sleeping with a different girl each week,or paying for sex at a brothal. When you look closely at these close minded people they have no-one but the ugly reflection of themselves to look at in the mirror each day. Men need woman more than women need men statistics have proven. Why is it men travel half way across the world to pay a girl for sex? hmm..
All of the people looking down at science are just taking a huge step backwards.
And if you are leaving a negative reply atleast have the ‘balls’ to leave your name mr .,. ‘??
Dr P Fenner
I think this is perfect, I don’t understand why some people are having such a shit fit over this. I’ve been searching for a way to have my girlfriend biologically attached to a child I wish to have. My girlfriend isn’t able to have children and a family means the world to her. It’s not fair when some people play this idea down and make it seem like sin. I love my girlfriend with every fiber in my being. And if there is any way to help this operation along, I will help whatever way I can.
~Kals
I for one will sign up to have my bone marrow taken and made into sperm. I want to have a child with my g/f and since the only person who can give us a child is my brother who has decided he wants nothing to do with it, I will gladly be a test subject so my g/f and I can have a kid that is both of ours!!!! Please contact me people!!!!
and as for mr .,. Don’t you think if gay people… every day gay people were allowed to adopt we would??!?!? I’m not talking about the super rich lesbians that can pay anyone off… I am talking about your middle class lesbian who works hard for everything she gets, comes home at the end of the day, lays with her woman knowing that she will never be able to give her a child of their own! That is what the is good for! And for that matter not all lesbians are man haters! I don’t hate men, I hate ignorant bigots like you!
Wow. If me and my gf could have a child that is our own it would make my life complete.
With regards to the male female parents being better argument, surely a child would be better having two mothers who both love them than they would in a ‘conventional’ family situation where the parents were seperated, one or the other was abusive ect. I lost my mother to cancer at an early age and was brought up by my father, i dont think i suffered for it, because i was loved. children need loving parents, thats all.
well really i love to use this in me.men are hypos…u can rely on them.see if its really happens i wud like to be the first and have the best baby in the earth….
well really i love to use this in me.men are hypos…u cant rely on them.see if its really happens i wud like to be the first and have the best baby in the earth….
This is a dificult situation. When experimenting on life, (even the early forms of life), we have to realize that what are manipulating is precious. My only problem would be the hundreds of innocent babies killed during botched attempts at female-female conception.
Women and Men need eachother equally, a world without either would be terrible. There is a reason we were made the way we are.
I agree with Alice. The amount of kids that will be killed in the process of try to have 1 may totally out way the good aspects of this.
Also i don’t think that it should matter who the kids would be for. Everyone’s equal and if a lesbian couple want to have a kid no problem.
I know a lot of kids with gay/lesbian parents and they are more normal than any of the other kids that have the “traditional” parents. It’s generally worse off if you have separated or abusive parents that same sex parents.
Let’s not forget that woman+woman reproduction will produce male in addition to female…
The input changes: instead of man+woman it’s woman+woman.
The output doesn’t change: women still have male and female babies.
Even if that turns out to be false and the only gender reproduced from woman+woman is female, then who will the woman turn to and blame for “that is so typical of a man”?
It will turn into a same-gender civil war, that is after the male gender has died out, and the female gender will only kill itself off.
Final result:
Human extinction.
Afterwards:
We’ll start all over with male+female humans by some freak of nature God (*not human*) creation.
Let the cycle replay unto itself and let us all hope that no gender - neither male nor female - is removed from the reproductive equation.
To all the women out there who are “anti-male” or femi-nazis:
You are the closest to a Nazi as ever anyone could be. Just replace the Jews/etc. with men and you’ve got the same thing only instead of doing it through something as morbid as the Holocaust it’d be done through science in its most morbid state.
For all of you - females - out there who feel the urge to praise, “finally!” to such a thing, you clearly forget the *good* that comes along with a woman being in love with a man.
Though, for those of you with such sick views, you either have never loved a man to discover the wonder in it or you have been burnt so bad that you must play the part of a teen rebel wannabe.
Love the man.
Reproduce with the man.
You will find out of the continued scientific discoveries in the more “females only, males need not apply” aspects of life that the strongest gender force yet will come out of it and only pinch the small flame of the likes of you out of existence.
And that group will be the masculinists.
…so to abbreviate, save yourselves the trouble and stick with what we’ve done such a great job at now for over 500,000 years: male+female reproduction.
What some of you don’t realize, or at least you aren’t acknowledging, is that this research will also help to give infertile men the chance to father a child. If this process were proven to be safe and I had the chance to have a child with my partner then I would certainly use it to my advantage.
P.S Why are these things filled with people who take their opinion and turn it into scientific fact? Has anyone else ever heard of research that proves that not having both male and female parents “messes you up?” Many many children are raised my single moms and single dads and they turn out to be quite succesful as adults.
-Val
I want to know if you can take one womens bone marrow and implant it into another womens egg to create a baby. Also I would like to know how much this procedure will cost. Thanks.
Guys, dont be so sensitive, heterosexual women will still mate with yall, but this is a great option for lesbians! So guys, you will not become “obselete” because most people who would use this idea would probably not be interested in mating with men anyways.
People that are for this idea are idiots, when will you people understand, that you are not gods, so stop trying to be him, you can say whatever you want, but i bet you any money, that if you do this, youre kids are going to come out as weak and disfigured abominations. there is a reason why a man and a women, fit perfectly into each, other, connect a female electric current, with another female electric current, and what do you get? an explosion! its just not meant to be, get rid of youre blind arrogance and accept the truth.
If they can do it, let them. Either way, this is pretty much impossible. Just a bunch of hype. If it were possible, I would be fine with it. How would this make me obsolete? Even if I could be made obsolete by someone else gaining reproductive freedoms, I’m still the man I am with all of the abilities, experiences, problems and advantages that come with being a man. If you think man’s importance comes solely from being able to impregnate a woman, then you are horribly wrong.
Also, the traditional way of reproducing would still be way more popular and convenient. Wham-bam, thank you mamn. Done. And people would likely pick a difficult genetic experiment over that? No way. That’s like taking a Buick over a Ferrari. Of course, for the people who only have a choice of the Buick, let ‘em drive.
By the way kids, leave the lesbians alone. Lesbians does not equal ‘man-hater’.
And once again I must say, “im-fuckin-possible” Even if it is, men and women will always need each other, despite sexual orientation or reproductive abilities.
ThIs WIll Be So Great AnD WoNDerFUL IF THiS ReAllY WORkS OUt..I CaNt WaIt..SO ME AnD My GiRlFrIend cAn Have Are OWn..
hahahahaha.
science cant change the true life cycle of human kind….
no such thing is true. if it was the they would have found a way to travel back to time..
hahahahahahahahahahaha
bull…..
hehehehehehehe.
science cant change the true life cycle of human kind….
no such thing is true. if it was the they would have found a way to travel back to time..
hahahahahahahahahahaha
bull…..
After reading all 44 comments, I don’t understand why there is a need for immature replies to be posted… (from non supporter.. with all the trashy and non-convincing words). Although, some of the non-supporters have proven a good point, with mature statements.
For me, myself, I’m a man with a wife and 2 kids. I totally support the project, and hope it can come true for those who needs it (IF, OF COURSE, THE BABY IS WELL AND NORMAL). Some non-supporters think that this will eliminate man, like ME, and You, and others. Wrong.
Think about it. Even though there are lesbian and gay couples out there, majority of human beings DO NOT support it. There are many Christian believers who are against it, the Republicans, and A LOT of people out there. Even if this technology becomes available in the future, not every single woman on earth will want to try it. Maybe just a little amount of them.
MEN WILL NEVER BE WIPED OFF THE SURFACE OF EARTH, and so is women. Support the project for those who really need it, who lacks the happiness of having a family with their own child. Not only gays and lesbians, but also those unfortunate infertile straight couples.
TO ALL SCIENCE CRITICS:
I suggested you people should try to live a life in a nation that is not adept to technology and sciences, like some parts of AFRICA, or the wilderness. No car, no phone, no computer, no internet, no medicine, no electricity, almost a NO to everything you’re enjoying right now. By then, you can come back and say you don’t appreciate it, with pride and honesty. Alright? Don’t criticize it, when you’re enjoying it very much. It’s ironic, and wrong!
TO ALL NON-SUPPORTERS:
Consider that we are humans and we always wanted to have as much choices and options as possible, maybe we should understand that others do want to have choices, too. (def)Choices - a list of things one can choose from. As this project is only an option, you can choose to do it or NOT AT ALL (IGNORE IT after it is available!!!), but it maybe something that someone wanted to do really bad, so maybe you guys can give in support to allow others to have choices, or just ignore it, so only supporters voice are heard. GOING AGAINST IT is just cruel because, if this is available, it does not really affect you, but at the same time increases others’ choices in life.
(peace out)
M.K.
well it’s about time. maybe now men will start to appreciate the female race as more than just an instrument for breading. Men, of course you wouldn’t agree with this article, it’s an attack on you “manhood”. I say who the hell cares women have sat in the male shadow for too long. now you will know how it feels to be not needed.
i love this article .i am papa from south africa .and im wondering if this can be used in my counrty aswel.if so which hospitals or practices/cant wait to have my own child
women can try to replace men all they want, but it will never happen, you need us,all these femenist’s are the same exact girls, who love getting their hair pulled, and getting spanked, hahahahahhahah…..you know it true:)
from worldly perspective: woman gonna end up trying to create man for heavy duty laboring.. fisherman, construction worker.. I would love to see woman get their hands on those “dirty” work as I barely seen any woman in the show “dirty job” in discovery channel.
Just how many women are willing to do the jobs men are doing, when all the men disappear. Don’t just look at all the men high up there in the society/spot light, look at the men that works at the most difficult environment.
end time is near.
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My girlfriend and i already have 2 kids together, a 3 and a half year old daughter and a 16 month old son. Our kids are perfectly normal. They are loved and cared for and isnt that what really matters?
This has got nothing to do with hating men, or trying to make them obsolete!
It is about creating life! Regardless of whether the couple is same sex or hetro. The same as it has always been.
My partner and i wish nothing more than to have a child biologically matching both of us. Which would open so many more options up.
Im sick of having to always having to try and defend myself and my family, we love, we live. Same as everyone else.
I just hope that the ethics boards see this for what it is, an fantastic opourtunity and a breakthrough.
As i read majoritory of these replies all i see is an attck on lesbians. Then all i think is why stop there? While your all at it why dont you attack everyone. Muslims, christians, african americans, jews. Whatever your personal views how can you feel you have the power to tell anyone how to live their lives or what to bleieve. This isnt just a discussion on using bone marrow to create immature sperm cells now. We arent talking about all the options this opens for everyone anymore.
And like they said, this could take up to 5 years! Why are we all debating the way people live their live? Thats not what this is about.
Imagine a couple that has been together for 20+ years, the husband gets cancer and no longer produces sperm as a result. They could now have children using this research. Thats remarkable. This wont break families down, but build them up!
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[…] is still only going to be for the people who want it.doesnt make men abselete,i love all the men …http://docinthemachine.com/2007/04/13/allfemalebaby-2/Helping women to have miracle babies - Belfast TelegraphIt takes four months for an egg to mature […]
Wow.
If this is really possible, I think it might be one of the best things science has brought us so far.. (My personal opinion).
This could be such a great opportunity for so many people. I myself am still young, and nowhere near ready to have children. I have no idea how I will end up, or with who. But I hope by the time I do, this technique will be widely accepted, and available to all.
Oh the feminists make such a big fuss about this one, trying to scare men into thinking the worlds going to be all female, Its going to be such great fun sticking a needle in your leg to get pregnant than having a man fuck you.
The thing is that you LOVE all the attention that men give to you, and youre just as selfish as men are about that. theres plenty of women who will stay with the guys because they want the attention just like men who want the sex.
Well maybe atleast it might make the men better looking
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