Comments on: The Power of Genetics and IVF Embryos- and the Controversy http://docinthemachine.com/2006/11/20/the-power-of-genetics-and-ivf-embryos-and-the-controversy/ Transforming medicine and fertility with tomorrow’s technology Wed, 08 Feb 2012 12:46:57 +0000 hourly 1 http://wordpress.org/?v=3.2.1 By: HP Wong PhD http://docinthemachine.com/2006/11/20/the-power-of-genetics-and-ivf-embryos-and-the-controversy/#comment-24852 HP Wong PhD Tue, 14 Aug 2007 12:41:53 +0000 http://docinthemachine.com/2006/11/20/the-power-of-genetics-and-ivf-embryos-and-the-controversy/#comment-24852 Mosaicism is quite common in embryos, it is because of the repeated cell division without the proper check of the disjunction of the chromosomes. Anyway, just to point out it is a functional feature that embryos, at the early stage, produce mosaic cells. Solution for PGS (PGD in UK)? Well, I know University College London takes two cells out of the eight for FISH just to eliminiate mosaicism and false positive. It works well. Of course, beside false result, there maybe downfall from performing PGD. Mosaicism is quite common in embryos, it is because of the repeated cell division without the proper check of the disjunction of the chromosomes. Anyway, just to point out it is a functional feature that embryos, at the early stage, produce mosaic cells.

Solution for PGS (PGD in UK)? Well, I know University College London takes two cells out of the eight for FISH just to eliminiate mosaicism and false positive. It works well.

Of course, beside false result, there maybe downfall from performing PGD.

]]> By: Beyond Genetic & Prenatal Testing- Pre-embryo Testing - Hiding the Results From the Patient » docinthemachine http://docinthemachine.com/2006/11/20/the-power-of-genetics-and-ivf-embryos-and-the-controversy/#comment-6795 Beyond Genetic & Prenatal Testing- Pre-embryo Testing - Hiding the Results From the Patient » docinthemachine Wed, 21 Mar 2007 22:39:44 +0000 http://docinthemachine.com/2006/11/20/the-power-of-genetics-and-ivf-embryos-and-the-controversy/#comment-6795 [...] Read more about PGD and controversy surrounding it here These icons link to social bookmarking sites where readers can share and discover new web pages. [...] [...] Read more about PGD and controversy surrounding it here These icons link to social bookmarking sites where readers can share and discover new web pages. [...]

]]> By: Steven F. Palter, MD http://docinthemachine.com/2006/11/20/the-power-of-genetics-and-ivf-embryos-and-the-controversy/#comment-415 Steven F. Palter, MD Sat, 25 Nov 2006 18:46:01 +0000 http://docinthemachine.com/2006/11/20/the-power-of-genetics-and-ivf-embryos-and-the-controversy/#comment-415 The deciding factor is likely the % cell normal vs abnormal which is clearly related to when in cell division the abnormality occurs and how well the abnormal cells divide. You are 100% correct about the multiple biopsy idea but with current technology this places a signififcant stress on the embryo and seems to reduce viability. In the future we will be biopsying the blatocyst (day 5-6) which has closer to a hundred cells. If we can get the genetic answer instantly (this is coming- today we need a day) then we can just biopsy multiple cells at this stage, get result, & replace normal embryo. The deciding factor is likely the % cell normal vs abnormal which is clearly related to when in cell division the abnormality occurs and how well the abnormal cells divide. You are 100% correct about the multiple biopsy idea but with current technology this places a signififcant stress on the embryo and seems to reduce viability. In the future we will be biopsying the blatocyst (day 5-6) which has closer to a hundred cells. If we can get the genetic answer instantly (this is coming- today we need a day) then we can just biopsy multiple cells at this stage, get result, & replace normal embryo.

]]> By: Judy http://docinthemachine.com/2006/11/20/the-power-of-genetics-and-ivf-embryos-and-the-controversy/#comment-414 Judy Sat, 25 Nov 2006 18:36:03 +0000 http://docinthemachine.com/2006/11/20/the-power-of-genetics-and-ivf-embryos-and-the-controversy/#comment-414 This is fascinating. It occurs to me that with a mosaicism, you are as likely to snag normal cells from a partly abnormal embryo, leaving it with fewer normal cells to outnumber the abnormal ones -- and not realize that you'd discarded what might actually be viable embryos in favor of non-viable ones. Multiple cell biopsies would seem to be a much more reasonable alternative than trusting single-cell biopsies. This is fascinating. It occurs to me that with a mosaicism, you are as likely to snag normal cells from a partly abnormal embryo, leaving it with fewer normal cells to outnumber the abnormal ones — and not realize that you’d discarded what might actually be viable embryos in favor of non-viable ones. Multiple cell biopsies would seem to be a much more reasonable alternative than trusting single-cell biopsies.

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